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KMID : 1149220080160020155
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Korean Journal of Oriental Medical Prescription
2008 Volume.16 No. 2 p.155 ~ p.162
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Inhibitory Effect of Mix proportion of Root of Scutellaria baicalensis and Coptis chinensis on LPS-induced type-I interferon Production in RAW264.7 Cells
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Kook Yoon-Bum
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Abstract
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Objectives : The present study was designed to investigate corelation between mix proportion of Scutellaria baicalensis (SB) and Coptis chinensis (CC) on lipopolysaccharide (LPS)-induced TYPE-1 interferon production.
Methods : I examined TYPE-1 interferon, interferon regulating factor (IRF)-1,7 and interleukin(IL)-10 production on LPS-induced RAW264.7 cells to evaluate inhibitory effect of mix proportion of SB and CC using real time PCR.
Results : Mixture of SB and CC regulated TYPE-1 interferon and IRF-1,7 mRNA expression with SB dose dependent manner, while maintained IL-10 mRNA expression on LPS-induced RAW264.7 cells.
Conclusion : In mixture of SB and CC, SB plays a key role in reducing TYPE-1 interferon through inactivation IRF-1,7. Furthermore mixture of SB and CC maintained IL-10 mRNA level. Collectively, this results suggest that SB confer beneficial effects in autoimmune diseases clinically.
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KEYWORD
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Scutellaria baicalensis, lipopolysaccharide (LPS), inflammation, interferon, IRF-1, 7, interferon regulatory factor
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